Research Pipeline Stage four: Preclinical Testing and Trial Design

Translation of bench research towards the clinic

The Centre will test lead candidates emerging from the pipeline in our preclinical mouse hospital in the context of ‘standard-of-care’ combination neurosurgery, fractionated irradiation and conventional chemotherapy. The pharmacokinetics, pharmacodynamics and potential biomarkers (tumour, liquid biopsy and imaging) of lead candidates will also be studied.We also can use these models to mimic a clinical setting Once established we can then use these models to assess drug efficacy and toxicology.

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