Publications

Recent publications from Centre members:

Targeting integrated epigenetic and metabolic pathways in lethal childhood PFA ependymomas

Science Translational Medicine. 2021 October

Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome

Nature Communications. 2021 February

Clinical Outcomes and Patient-Matched Molecular Composition of Relapsed Medulloblastoma

Journal of Clinical Oncology. 2021 January

Orally bioavailable CDK9/2 inhibitor shows mechanism-based therapeutic potential in MYCN-driven neuroblastoma

Journal of Clinical Investigation. 2020 November

DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma

Developmental Cell. 2020 July

Tumor Necrosis Factor Overcomes Immune Evasion in p53-mutant Medulloblastoma

Nature Neuroscience. 2020 May

Germline Elongator mutations in Sonic Hedgehog medulloblastoma

Nature. 2020 April

Public resources for chemical probes: the journey so far and the road ahead.

Future Medicinal Chemistry. 2019 November

Recurrent non-coding U1-snRNA mutations drive cryptic splicing in Shh medulloblastoma.

Nature. 2019 October

DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome.

Nature. 2019 September

YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis.

Nature Comms. 2019 September

Reply to ‘Assembling the brain trust: the multidisciplinary imperative in neuro-oncology’.

Nat Rev Clin Oncol 2019 August

Challenges to curing primary brain tumours.

Nat Rev Clin Oncol 2019 August

Pharmacokinetics and safety of erlotinib and its metabolite OSI-420 in infants and children with primary brain tumors.

Cancer Chemother Pharmacol 2019 August

Resolving medulloblastoma cellular architecture by single-cell genomics

Nature. 2019 July

Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma

Cancer Research. 2019 May

Small-molecule targeting of brachyury transcription factor addiction in chordoma.

Nature Medicine. 2019 February