Paediatric Brain Tumour Biology and Models

We will advance the understanding of the basic biology of paediatric brain tumours by developing and studying highly-accurate models for paediatric brain tumours. These models include genetically engineered mouse models (GEMMs) and patient-derived orthotopic xenografts (PDOXs).  These models will be used to identify the cellular origins of these tumours and discover genetic drivers and cell hierarchies that maintain the tumours.

The groups involved in this stage of the pipeline are:

A list of available models can be found on our Preclinical Mouse Repository page.