On October 4th 2021, the Children’s Brain Tumour Centre of Excellence held it’s first annual Centre Symposium post covid-19. This one day symposium brought together researchers of the host Institutes, the University of Cambridge and the Institute of Cancer Research after nearly two years of online meetings! It was a fantastic day of interesting science, poster presentations and discussions on our current and future collaborations. We had guest speakers from St Jude Children’s Hospital, USA and DKFZ in Germany. The day finished with a meeting with the International Children’s Brain Tumour Board which convened to share current data and evaluate work in the CBTCE.