Generated by All in One SEO Pro v5.0.1.1, this is an llms.txt file, used by LLMs to index the site.

# CRUK

Children's Brain Tumour Centre of Excellence

## Sitemaps

- [XML Sitemap](https://www.crukchildrensbraintumourcentre.org/sitemap.xml): Contains all public & indexable URLs for this website.

## Posts

- [News](https://www.crukchildrensbraintumourcentre.org/news/)
- [Centre co-director Paul Workman releases chemical probes podcast](https://www.crukchildrensbraintumourcentre.org/news/2025/01/28/centre-co-director-paul-workman-releases-chemical-probes-podcast/) - We have talked in the past at summer schools and so on about the importance of chemical probes in biomedical research and my role leading the Chemical Probes Portal www.chemicalprobes,org I thought CBTCE members might be interested in the following link to my debut podcast on Spotify, which dropped yesterday, where I talk about chemical
- [2024 International Summer School ‘Childhood Cancer Research in the Era of Big Data'](https://www.crukchildrensbraintumourcentre.org/news/2024/08/28/2024-international-summer-school-childhood-cancer-research-in-the-era-of-big-data/) - We are delighted to report on the success of the 2024 International Summer School ‘Childhood Cancer Research in the Era of Big Data’ held at Trinity Hall WYNG Gardens in Cambridge. We welcomed 54 delegates from across Europe, North America and Asia including PhD candidates, Clinical fellows, Masters Students and Postdoctoral Research Associates. Highlights from
- [Professor Paul Workman Our CRUK CBTCE co-director receives the 2024 International Chemical Biology Society Global Lectureship Award](https://www.crukchildrensbraintumourcentre.org/news/2024/09/02/professor-paul-workman-our-cruk-cbtce-co-director-receives-the-2024-international-chemical-biology-society-global-lectureship-award/) - We are delighted to announce that Professor Paul Workman, our CRUK CBTCE co-director, has been recognised for his outstanding contributions in cancer drug discovery, as well as being a role model and leader to the global chemical biology community with the 2024 International Chemical Biology Society Global Lectureship Award. Read more here: https://www.chemical-biology.org/page/ICBS2024Awards Congratulations Paul!
- [EPCAM 2024](https://www.crukchildrensbraintumourcentre.org/news/2024/08/27/epcam-2024/) - We are pleased to report that our third Ependymoma Science (EpCam) meeting was held in July 2024 in Cambridge, UK. This meeting was funded by the major sponsor the Robert Connor Dawes (RCD) Foundation with support from Texas Children’s Hospital and Cancer Research UK. Overall, 28 leading experts in ependymoma research attended from UK, Australia,
- [It is with great sadness that we learnt of the recent passing of our colleague Dr Neil Thompson](https://www.crukchildrensbraintumourcentre.org/news/2024/05/07/it-is-with-great-sadness-that-we-learnt-of-the-recent-passing-of-our-colleague-dr-neil-thompson/) - It is with great sadness that we learnt of the recent passing of our colleague Dr Neil Thompson who was due to participate as a distinguished speaker at the CRUK Children’s Brain Tumour Centre of Excellence International Summer School this July. We offer our sincere condolences to his family and friends.
- [CBTCE International Summer School 2024 - Childhood Brain Tumour Research In The Era Of Big Data: Confirmed Speaker Announcement](https://www.crukchildrensbraintumourcentre.org/news/2023/08/17/cruk-childrens-brain-tumour-centre-of-excellence-international-summer-school-2024-speaker-lineup/) - Applications are now open, you can find the form here We are delighted to confirm that Dr Bissan Al-Lazikani will be a keynote speaker at the Centre’s International Summer School 2024. Bissan Al-Lazikani FRSB MBCS is a data scientist and drug discoverer with experience in academia and industry. She is Professor, Genomic Medicine; Director of
- [Early career research scientists … come along to our new engagement series  hosted by the Brain Cancer Virtual Institute, the CRUK Children’s Brain  Tumour Centre of Excellence and CRUK RadNet Cambridge.](https://www.crukchildrensbraintumourcentre.org/news/2024/01/08/early-career-research-scientists-come-along-to-our-new-engagement-series-hosted-by-the-brain-cancer-virtual-institute-the-cruk-childrens-brain-tumour-centre-of-excellence-and-cru/) - Early career research scientists have been invited to attend our along to our new engagement series hosted by the Brain Cancer Virtual Institute, the CRUK Children’s Brain Tumour Centre of Excellence and CRUK RadNet Cambridge. Take a look at some of the Events coming up .. SCIENTIFIC SPEED DATING - Tues 30th January 08:30 -
- [The 2024 Medulloblastoma in the Mountains meeting, the 11th in the series across the globe](https://www.crukchildrensbraintumourcentre.org/news/2024/02/14/the-2024-medulloblastoma-in-the-mountains-meeting-the-11th-in-the-series-across-the-globe/) - The 2024 Medulloblastoma in the Mountains meeting, the 11th in the series across the globe, took place January 21-24, 2024, at North Lake Tahoe, California. The 42 invited, leading researchers who participated traveled from Japan, China, Australia, Germany, France, Sweden, the United Kingdom, Canada, and the United States. As always, the focus was on breaking translational research
- [CRUK Children's Brain Tumour Centre of Excellence International Summer School 2024](https://www.crukchildrensbraintumourcentre.org/news/2023/07/25/cruk-childrens-brain-tumour-centre-of-excellence-international-summer-school-2024/) - We are excited to announce the theme of the CRUK Children's Brain Tumour Centre of Excellence International Summer School 2024: Childhood Brain Tumour Research In The Era Of Big Data The Summer School will be held at Trinity Hall, Cambridge from 17th - 19th July 2024. The sessions will include topics such as; AI and Machine
- [EpCam 2023 meeting Overview](https://www.crukchildrensbraintumourcentre.org/news/2023/08/09/epcam-2023-meeting-overview/) - EpCam 2023 meeting Overview Following the success of EPCam 2022, we are delighted to report that the second Ependymoma Science meeting was held in June 2023 in Cambridge, UK. This meeting was supported by the major sponsors Robert Connor Dawes Foundation and also Texas Children’s Hospital and Cancer Research UK. Overall 23 leading experts in
- [CRUK Children's Brain Tumour Centre of Excellence held our first International Summer School](https://www.crukchildrensbraintumourcentre.org/news/2022/09/21/cruk-childrens-brain-tumour-centre-of-excellence-held-our-first-international-summer-school/) - The Centre was delighted to hold the first International Summer School at Homerton College in July 2022. Due to the Covid-19 pandemic, the summer schools for 2020 and 2021 were cancelled, therefore we were especially excited to hold the 2022 event and offer the chance for Early Career Research Scientists to come together in person.
- [First paper from the Pathania Group](https://www.crukchildrensbraintumourcentre.org/news/2023/04/18/test-2/) - An exciting paper from one of the Centre's group leaders, Dr Pathania is now published in Cancer Discovery! This was a huge effort that involved the generation of multiple models, identification of targeted therapy opportunities, and their Transatlantic partnership with collaborators. Many congratulations to the Pathania group for this fantastic research on high grade gliomas.
- [World leaders in medulloblastoma researchers gather at 'Medulloblastoma in the Mountains' meeting](https://www.crukchildrensbraintumourcentre.org/news/2023/04/26/world-leaders-in-medulloblastoma-researchers-gather-at-medulloblastoma-in-the-mountains-meeting/) - This January 2023 the annual meeting of clinical and scientific medulloblastoma experts was held in beautiful Cape Town. Forty international leaders in the medulloblastoma field and five local delegates attended the meeting. This meeting facilitates a worldwide community that works collaboratively and is in a unique position to ensure that change happens. The overarching aims
- [Emily Parsons Fundraising](https://www.crukchildrensbraintumourcentre.org/news/2022/01/01/emily-parsons-fundraising/) - In December 2021 the Centre and the Milner Institute were finally able to host the Parsons-Smart family in person to show them around the Pathania lab and talk about science and the amazing contribution Emily Parsons and her family have made to the work in the Centre. Emily single-handedly raised over £100,000 for research into
- [CRUK prioritises children’s and young people’s cancer research](https://www.crukchildrensbraintumourcentre.org/news/2019/10/10/cruk-prioritises-childrens-and-young-peoples-cancer-research/) - To kick off the start of childhood cancer awareness month, September 2019, CRUK launched its new strategy to support the research of childhood cancers and to tackle the challenges in this field. CRUK will prioritise children’s and young people’s cancer research to better understand these diseases and to develop more effective, less toxic treatments that
- [Brain Tumours and COVID-19](https://www.crukchildrensbraintumourcentre.org/news/2020/05/20/brain-tumours-and-covid-19/) - Here are some useful links for clinicians, researchers and others working in neuro-oncology during this pandemic: Adult and Paediatric Guidelines from the British Neuro-oncology Society https://www.bnos.org.uk/clinical-practice/treatment-pathways-and-guidance/ Guidance for patients from The Brain Tumour Charity https://www.thebraintumourcharity.org/media-centre/news/charity-news/cor… CovidSurg Cancer Study – collecting data on cancer patients requiring surgery https://globalsurg.org/cancercovidsurg/ COVIDNeuroOnc – A national study to determine the
- [The Centre hosts the first Ependymoma Science meeting 'EpCam 2022'](https://www.crukchildrensbraintumourcentre.org/news/2022/07/27/test/) - In June 2022, the CRUK Children’s Brain Tumour Centre of Excellence hosted an international ependymoma meeting in Cambridge, sponsored by the Robert Connor Dawes Foundation. Held at the Hilton Hotel, World leaders in ependymoma research gathered to share their work with peers in order to both advance and expedite discoveries in the field to improve
- [Cambridge Festival 2023](https://www.crukchildrensbraintumourcentre.org/news/2023/04/02/cambridge-festival-2023/) - The Centre was delighted to attend this years Cambridge Festival which was held on Saturday 18 March. This was a fantastic opportunity for the public to learn more about the ground-breaking cancer research being undertaken by scientists and clinicians across Cambridge! The Centre presented the work being carried out as part of the Brain
- [Open Academy](https://www.crukchildrensbraintumourcentre.org/news/2023/04/06/open-academy/)
- [Annual Symposium 2021](https://www.crukchildrensbraintumourcentre.org/news/2021/11/26/annual-symposium-2021/) - On October 4th 2021, the Children’s Brain Tumour Centre of Excellence held it’s first annual Centre Symposium post covid-19. This one day symposium brought together researchers of the host Institutes, the University of Cambridge and the Institute of Cancer Research after nearly two years of online meetings! It was a fantastic day of interesting science,
- [Cambridge Festival 2022](https://www.crukchildrensbraintumourcentre.org/news/2023/03/26/cambridge-festival-2022/) - On Saturday 2 April, 11am-4pm, in the Hopkins Building the Centre took part in a fun-filled day of hands-on scientific activities and games as part of the Cambridge Festival 2022! We presented the exciting research being carried out in the CRUK Children's Brain Tumour Centre of Excellence and the new Brain Cancer Virtual Institute, showcasing
- [Tessa Jowell Brain Cancer Mission Announces New Initiative](https://www.crukchildrensbraintumourcentre.org/news/2020/05/12/tessa-jowell-brain-cancer-mission-announces-new-initiative/) - Today, two years on from Dame Tessa Jowell’s passing, Tessa’s legacy remains strong as the Tessa Jowell Brain Cancer Mission (TJBCM) announces its plans to found a national network of Tessa Jowell Centres of Excellence for brain tumour treatment and care in adults. This initiative is driven by, and for, the community of people living
- [First Annual Centre Symposium](https://www.crukchildrensbraintumourcentre.org/news/2019/11/05/first-annual-centre-symposium/) - On Monday, November 4, 2019, the Children’s Brain Tumour Centre of Excellence held it’s first annual Centre Symposium. This one day symposium brought together researchers of the two host Institutes, the University of Cambridge and the Institute of Cancer Research. It was a great day of exciting science, discussions on how to boost collaborations and
- [Cancer survivor calls on Suffolk to kickstart vital research](https://www.crukchildrensbraintumourcentre.org/news/2020/07/22/cancer-survivor-calls-suffolk-kickstart-research/) - This month, July 2020, Charlie Williams, from Sudbury, celebrated his 21st birthday party with family and friends. It was a very special day for Charlie because, not only was it a milestone birthday, it was also a time to reflect on how much he had achieved in his life.
- [The Tessa Jowell Brain Cancer Mission](https://www.crukchildrensbraintumourcentre.org/news/2019/10/10/the-tessa-jowell-brain-cancer-mission/) - Following Tessa Jowell’s call for action to improve brain tumour treatment, research and survival, the Tessa Jowell Brain Cancer Mission (TJBCM) was formed.

## Pages

- [Home](https://www.crukchildrensbraintumourcentre.org/)
- [Cookies & Privacy Policy](https://www.crukchildrensbraintumourcentre.org/cookies-privacy-policy/) - Privacy Policy 1. Children’s Brain Tumour Centre of Excellence takes your privacy seriously. This policy outlines the use of personal data under the Data Protection Act 1998 (“DPA”) and the General Data Protection Regulations (“GDPR”) 2. 2. For the purpose of DPA and GDPR we are the data controller and any enquiry regarding the collection
- [People](https://www.crukchildrensbraintumourcentre.org/about-2/people/)
- [Lets Collaborate](https://www.crukchildrensbraintumourcentre.org/lets-collaborate/)
- [Summer School 2024](https://www.crukchildrensbraintumourcentre.org/news/summer-school-2024/) - We are delighted to report on the success of the 2024 International Summer School ‘Childhood Cancer Research in the Era of Big Data’ held at Trinity Hall WYNG Gardens in Cambridge. We welcomed 54 delegates from across Europe, North America and Asia including PhD candidates, Clinical fellows, Masters Students and Postdoctoral Research Associates. Highlights from
- [Welcome to our 2024 International Summer School](https://www.crukchildrensbraintumourcentre.org/research-professionals/events/welcome-to-our-2024-international-summer-school/) - Welcome We are pleased to welcome you to our International Summer School 2024. Please scroll down below to find information on the programme, our fantastic speakers and a welcome note from the Centre! Welcome from the Centre directors, Professors Richard Gilbertson and Paul Workman On behalf of the CRUK Children’s Brain Tumour Centre of Excellence
- [The 2024 Medulloblastoma in the Mountains meeting, 11th In the Series](https://www.crukchildrensbraintumourcentre.org/the-2024-medulloblastoma-in-the-mountains-meeting-11th-in-the-series/) - The 2024 Medulloblastoma in the Mountains meeting, the 11th in the series across the globe, took place January 21-24, 2024, at North Lake Tahoe, California. The 42 invited, leading researchers who participated traveled from Japan, China, Australia, Germany, France, Sweden, the United Kingdom, Canada, and the United States. As always, the focus was on breaking translational research
- [Research Pipeline](https://www.crukchildrensbraintumourcentre.org/research-professionals/research-pipeline/) - Our research strategy is centred around our biology and drug discovery pipeline: leveraging the existing expertise; recruiting and training new expertise; facilitating innovative and iterative research; and engaging international collaborators through our board members, the International Children's Brain Tumour Board. Our pipeline consists of the following four stages: Stage One: Paediatric Brain Tumour Biology and
- [Research Pipeline Stage Two: Drug Target Identification](https://www.crukchildrensbraintumourcentre.org/research-pipeline-stage-two-drug-target-identification/) - What is drug target identification? Work in the Centre is ongoing to discover tumour cell proteins and pathways (targets) critical for maintaining the malignant phenotype that may serve as therapeutic targets. This research is iterative and allows insights into tumour biology generated in stage one activities and collaborative input from the International Children's Brain Tumour
- [Collaborating Organisations](https://www.crukchildrensbraintumourcentre.org/collaborating-organisations/) - At the Centre we collaborate and are engaged with many organisations. We are pleased to be connected with organisations worldwide united in our goal of supporting children's brain tumour research and the research community. Please continue reading below to find out more about our friends and organisations who we work closely at the centre on
- [Research Pipeline Stage One: Paediatric Brain Tumour Biology and Models](https://www.crukchildrensbraintumourcentre.org/research-professionals/research-pipeline/research-pipeline-stage-one-paediatric-brain-tumour-biology-and-models/) - Why do we need accurate models? Accurate models are important to advance our understanding of the basic biology of paediatric brain tumours such as how the tumours develop and grow. These models include cell lines, genetically engineered mouse models (GEMMs) and patient-derived orthotopic xenografts (PDOXs).We perform techniques such as single cell sequencing to find out
- [Research Pipeline Stage four: Preclinical Testing and Trial Design](https://www.crukchildrensbraintumourcentre.org/research-pipeline-stage-four-preclinical-testing-and-trial-design/) - Translation of bench research towards the clinic The Centre will test lead candidates emerging from the pipeline in our preclinical mouse hospital in the context of ‘standard-of-care’ combination neurosurgery, fractionated irradiation and conventional chemotherapy. The pharmacokinetics, pharmacodynamics and potential biomarkers (tumour, liquid biopsy and imaging) of lead candidates will also be studied.We also can use
- [Research Pipeline Stage Three: Drug Design and Discovery](https://www.crukchildrensbraintumourcentre.org/research-pipeline-stage-three-drug-design-and-discovery/) - Drug Discovery in the Centre Scientists in the Centre are working on designing novel drugs including small molecules and PROTACs to treat different children’s brain tumours. Ongoing work is focused on ependymoma and high grade glioma, with the aim to identify, prioritise and optimise inhibitors of lead targets validated. This work is led by the
- [Projects](https://www.crukchildrensbraintumourcentre.org/about-2/projects/) - Read below about some of the Centre projects across the different areas of children's brain tumour research. New Therapies for Ependymoma Fully funded by the Centre and led by the Medicinal Chemistry team at ICR and the Gilbertson lab in the University of Cambridge, one of our key projects is the discovery and development of
- [Contact](https://www.crukchildrensbraintumourcentre.org/contact/) - Contact us using the details below CRUK Children’s Brain Tumour Centre of Excellence Cancer Research UK Cambridge Institute University of Cambridge Li Ka Shing Centre Robinson Way Cambridge Biomedical Campus Cambridge CB2 0RE Telephone: 01223 769811 Email: cbtce@cancer.cam.ac.uk Alternatively, you can contact us by filling in the form below.
- [Research Professionals](https://www.crukchildrensbraintumourcentre.org/research-professionals/) - The Centre brings together researchers across the Children's Brain Tumour community. We welcome new project ideas and opportunities to collaborate through our online portal. Our research strategy is based on our biology and drug discovery and development pipeline and we have several resources for the research community, including; characterised models and cell lines, toxicity data
- [Patient Resources](https://www.crukchildrensbraintumourcentre.org/patient-resources/) - Brain and spinal cord tumours are the second most common group of children's cancers and are the most common cause of cancer-related death in children. Survival for some children's brain tumours hasn't improved much since the 1970s, and for those who do recover often long-term side effects from treatment impacts quality of life. Limited progress
- [Diffuse Midline Glioma Network](https://www.crukchildrensbraintumourcentre.org/patient-resources/diffuse-midline-glioma-network/) - Coming soon ...
- [Resources](https://www.crukchildrensbraintumourcentre.org/research-professionals/resources/)
- [Tessa Jowell Centres of Excellence for Children](https://www.crukchildrensbraintumourcentre.org/patient-resources/tessa-jowell-centre-of-excellence-for-children/) - In 2020-2021 Tessa Jowell Centre of Excellence designation initiative was established to recognise and award neuro-oncology centres for their excellence in patient treatment and care and research. It aims to enable and encourage as many centres as possible to achieve ‘Centre of Excellence’ designation to collectively raise the bar and set an example across the
- [About Children's Brain Tumours](https://www.crukchildrensbraintumourcentre.org/patient-resources/about-childrens-brain-tumours/) - Ependymoma Ependymoma is a type of brain and spinal cord tumour and is the third most common brain tumour in children. Ependymoma are most common in children under 5 years old and occur more frequently in boys than in girls. Ependymomas usually start from ependymal cells. These cells line the fluid filled areas of the
- [About](https://www.crukchildrensbraintumourcentre.org/about-2/) - Why is it important to research children's brain tumours? Brain tumours remain the most common cause of cancer-related death in children. Limited progress in these diseases relates directly to the use of inaccurate preclinical pipelines that fail to identify drugs with activity in patients. Accurate preclinical pipelines are especially important for rare cancers, such as
- [Patient Stories](https://www.crukchildrensbraintumourcentre.org/patient-resources/patients-story/patient-stories/) - Norfolk dad reveals hidden loving tribute to his four-year old daughter for Father’s Day as she recovers from two year cancer battle Aaron Lambert, got a tattoo on the back of his head to match his daughter's brain surgery scar after a life-saving operation. The 36-year-old self-employed decorator is sharing his story to raise awareness and back
- [Publications](https://www.crukchildrensbraintumourcentre.org/publications/) - Recent publications from Centre members: Targeting integrated epigenetic and metabolic pathways in lethal childhood PFA ependymomas Science Translational Medicine. 2021 October Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome Nature Communications. 2021 February Clinical Outcomes and Patient-Matched Molecular Composition of Relapsed Medulloblastoma Journal of Clinical Oncology. 2021 January Orally bioavailable CDK9/2 inhibitor
- [Events](https://www.crukchildrensbraintumourcentre.org/research-professionals/events/)
- [Training and Development for Early Career Researchers](https://www.crukchildrensbraintumourcentre.org/research-professionals/training-and-development-for-early-career-researchers/)
- [Join our community](https://www.crukchildrensbraintumourcentre.org/im-a-researcher-and-i-would-like-to-join-the-centre-community/)
- [New Projects and Collaborations](https://www.crukchildrensbraintumourcentre.org/research-professionals/new-projects/) - The CRUK Children’s Brain Tumour Centre of Excellence's goal is to foster boarder collaborations within the research and clinical community to ensure that the most effective treatments are taken to the clinic. Our network has expertise across multiple disciplines including basic biology, machine learning, pharmacology and chemistry. We have multiple resources at our fingertips including
- [Patient Stories](https://www.crukchildrensbraintumourcentre.org/patient-resources/patients-story/) - Charlie Williams, from Sudbury UK was just five years old when he was diagnosed with the brain tumour medulloblastoma in May 2005. He had months of treatment at the Addenbrooke’s Hospital in Cambridge, UK, including a seven hour operation, radiotherapy twice a day for five weeks and a year of chemotherapy. He missed two years
- [Terms of Use](https://www.crukchildrensbraintumourcentre.org/terms-of-use/) - By accessing this site, you agree to the following terms and conditions and other applicable laws. If you do not agree to be bound by these terms and conditions, please do not use this website. All the information and material provided on this web site is solely for illustrative purposes. It is not intended to,

## Team

- [Dr Emily Linnane](https://www.crukchildrensbraintumourcentre.org/people/entry/dr-emily-linnane/) - Emily is an Assistant Research Professor and the Scientific Manager of the CRUK Children’s Brain Tumour Centre of Excellence. She is based at the University of Cambridge, CRUK Cambridge Institute. Emily obtained her MRes in Molecular Oncology and PhD in Cellular and Molecular Physiology at the University of Liverpool. She later worked for an oncology
- [Dr Bissan Al-Lazikani](https://www.crukchildrensbraintumourcentre.org/people/entry/dr-bissan-al-lazikani/) - Bissan Al-Lazikani FRSB MBCS is a data scientist and drug discoverer with experience in academia and industry. She is Professor, Genomic Medicine; Director of Discovery Data Science and founding faculty of the Data Science Institute at MD Anderson Cancer Center. Prior to this, she was Head of Data Science at the Institute of Cancer Research, London.
- [Dr Gary Newton](https://www.crukchildrensbraintumourcentre.org/people/entry/prof-ian-collins/) - Dr Gary Newton Dr Gary Newton is a Team Leader at the Institute of Cancer Research. He is a member of the Centre for Cancer Drug Discovery where he applies his medicinal chemistry experience to validate new targets and develop effective medicines for the treatment of cancer. He has worked in biotech and contract research
- [Dr Steven Niederer](https://www.crukchildrensbraintumourcentre.org/people/entry/dr-steven-niederer/) - Dr. Steven Niederer completed his undergraduate degree in Engineering Science at the University of Auckland in 2003 and his DPhil in Computer Science on modelling the rat heart at the University of Oxford in 2008. From 2010 to 2023 he started and grew the Cardiac Electro-Mechanics Research Group at King’s College London, where his research
- [Professor Petra Hamerlik](https://www.crukchildrensbraintumourcentre.org/people/entry/professor-petra-hamerlik-phd/) - Petra Hamerlik is an accomplished researcher in primary pharmacology and brain cancer research. Her professional career has been a blend of academic and industry roles, including positions at the Danish Cancer Society, Cleveland Clinic, and AstraZeneca. In September 2022, Petra was recruited to the University of Manchester as the Inaugural Brain Tumour Charity Chair of
- [Professor Paul Workman](https://www.crukchildrensbraintumourcentre.org/people/entry/prof-paul-workman/) - Professor Paul Workman Paul Workman is Harrap Professor of Pharmacology and Therapeutics at The Institute of Cancer Research, London. He is renowned for his research on the discovery and mechanistic investigation of cancer drugs and chemical probes – including inhibitors of protein kinases, PI3 kinases, molecular chaperones including HSP90 and HSP70, and the Heat Shock
- [Dr Marcel Kool](https://www.crukchildrensbraintumourcentre.org/people/entry/dr-marcel-kool/) - Dr Kool studies the genomics and epigenomics of pediatric brain tumors and how to translate findings from these studies into novel therapies. More effective and less toxic therapies are highly needed as there are many types of childhood brain tumors for which the survival is still very poor or where survivors suffer from serious long-term
- [Professor Steve Pollard](https://www.crukchildrensbraintumourcentre.org/people/entry/professor-steve-pollard/) - Based at our Edinburgh Centre(link is external), Professor Steven Pollard and his team are working to better understand brain stem cells and their potential role in ‘glioblastoma’ – a fast-growing type of brain cancer. Brain stem cells are amazing cells that can change their characteristics to become any kind of specialist cell in the brain. Before
- [Dr Anang Shelat](https://www.crukchildrensbraintumourcentre.org/people/entry/dr-anang-shelat/) - Dr. Anang Shelat is an expert in chemical informatics and assay development, with an expanding portfolio of innovative and collaborative research efforts. His scientific journey began at Harvard, continued at UCSF, and ultimately led to postdoc fellowship and faculty appointment at St. Jude. Dr. Shelat and his team developed invaluable analytical tools for drug screening
- [Dr Amy Smith](https://www.crukchildrensbraintumourcentre.org/people/entry/dr-amy-smith/) - Amy Smith, MD, is a neuro-oncologist and part of the pediatric hematology/oncology team with The Haley Center for Children's Cancer and Blood Disorders at Orlando Health Arnold Palmer Hospital for Children. She is board certified in pediatrics and pediatric hematology/oncology. Dr. Smith earned her medical degree from the Medical College of Georgia in Augusta, and
- [Professor Steven Clifford](https://www.crukchildrensbraintumourcentre.org/people/entry/professor-steven-clifford/) - Professor Clifford is Chair of Molecular Paediatric Oncology and directs the Newcastle University Centre for Cancer. He co-leads our Childhood Brain Tumour Research team (25 scientists/clinicians), with major interests in understanding the biological basis of embryonal brain tumour development (principally medulloblastoma), and translating these findings into improved clinical treatments. His international bench-to-bedside programme in medulloblastoma has been central
- [Dr Kristian Pajtler](https://www.crukchildrensbraintumourcentre.org/people/entry/dr-kristian-pajtler/) - Dr Pajtler leads the Early Cancer Diagnostics team which consists of members with a background in biology, biotechnology, bioinformatics or medicine. They are strongly involved in all three major programs of the Hopp Children’s Cancer Center. Preclinical, translational and clinical research is conducted in three closely interconnected focus areas outlined below. These aim at improvement
- [Dr Pau Creixell](https://www.crukchildrensbraintumourcentre.org/people/entry/dr-pau-creixell/) - Pau studied Human Biology at the Universitat Pompeu Fabra, Barcelona, before moving to Oxford, London and the Technical University of Denmark where he obtained his PhD in Computational Biology. He then received a postdoctoral fellowship from the Helen Hay Whitney Foundation to pursue his studies at the Koch Institute for Integrative Cancer Research at MIT.
- [Professor Paul Lehner](https://www.crukchildrensbraintumourcentre.org/people/entry/professor-paul-lehner/) - Professor Lehner is a Clinician Scientist and Immunobiologist at the University of Cambridge. He obtained his medical degree from University College London and PhD from the University of Cardiff. Paul is distinguished for his work on the cell biology of immune and viral evasion pathways. Prominent among these are his discoveries of how the vertebrate
- [Dr Michael Taylor](https://www.crukchildrensbraintumourcentre.org/people/entry/dr-michael-taylor/) - Dr Taylor is the director of the Neuro-oncology Research Program at Texas Children's Hospital. He was previously working as a paediatric neurosurgeon and senior scientist at University of Toronto affiliated Hospital for Sick Children. His research centres on the molecular genetics of medulloblastoma and ependymoma, two of the most common malignant paediatric brain tumours. He
- [Dr Michelle Monje](https://www.crukchildrensbraintumourcentre.org/people/entry/dr-michelle-monje/) - Michelle Monje, MD, PhD, is a Professor of Neurology and Neurological Sciences at Stanford University and a Howard Hughes Medical Institute Investigator. She received her M.D. and Ph.D. in Neuroscience from Stanford and completed her residency training in neurology at the Massachusetts General Hospital/Brigham and Women's Hospital/Harvard Medical School Partners program, and then returned to
- [Dr Peter Dirks](https://www.crukchildrensbraintumourcentre.org/people/entry/dr-peter-dirks/) - The Dirks Lab is focused on the biology of brain tumours of children and adults, with a primary aim to understand the link between stem cell biology, development, and brain tumor growth, and a secondary aim to understand brain tumour heterogeneity and how diverse cell types contribute to tumour maintenance and therapeutic resistance.
- [Professor Darren Hargrave](https://www.crukchildrensbraintumourcentre.org/people/entry/professor-darren-hargrave/) - Professor Hargrave joined Great Ormond Street Hospital (GOSH) in 2011 having previously worked at The Royal Marsden Hospital in London. He was appointed in 2017 as the GOSH Children’s Charity Clinical Professor in Paediatric Neuro-oncology. Prof Hargrave specialises in paediatric neuro-oncology and the development of new anti-cancer drugs for children and adolescents. He trained in the
- [Professor Tom Jacques](https://www.crukchildrensbraintumourcentre.org/people/entry/professor-tom-jacques/) - Professor Jacques is Professor of Paediatric Neuropathology at the UCL Great Ormond Street Institute of Child Health and Clinical Lead/Laboratory Director for the department of histopathology at Great Ormond Street Hospital for Children in London. He runs a research programme focussed on paediatric brain tumours and epilepsy. He has been an investigator on over £25
- [Dr Luis F. Parada](https://www.crukchildrensbraintumourcentre.org/people/entry/dr-luis-f-parada/) - Luis F. Parada obtained a BS from the University of Wisconsin and a Ph.D. in Biology from MIT, identifying oncogenes in human cancer. He was a Damon Runyon and Helen Hay Whitney Postdoctoral Fellow at the Pasteur Institute. He headed the Molecular Embryology Section at the National Cancer Institute in Frederick, MD from 1988 to
- [Dr Manav Pathania](https://www.crukchildrensbraintumourcentre.org/people/entry/dr-manav-pathania/) - Manav received a BA in Biology from Grinnell College, in Iowa, and received his PhD in Cell Biology from Yale University, in Connecticut. At Yale he investigated microRNA control of postnatal neural stem cell differentiation and survival in Professor Angelique Bordey’s lab. His first postdoctoral appointment was in Professor Josef Kittler’s lab at UCL in
- [Professor Chris Jones](https://www.crukchildrensbraintumourcentre.org/people/entry/professor-chris-jone/) - Professor Chris Jones Professor Chris Jones and his team concentrate on scanning the genome and epigenome of paediatric brain tumours. Their aim is to find the genes that are driving development of these cancers, and identifying ways to translate these findings into new treatments for children with these tumours. The team focuses on paediatric high
- [Dr Paul Northcott](https://www.crukchildrensbraintumourcentre.org/people/entry/dr-paul-northcott/) - Paul Northcott received his PhD from the University of Toronto and completed his postdoctoral training at the Hospital for Sick Children in Ontario, Canada, and the German Cancer Research Center in Heidelberg, Germany. His prolific and impactful work as a trainee led to a faculty appointment in 2015 at St. Jude, where he continues to
- [Prof Stefan Pfister](https://www.crukchildrensbraintumourcentre.org/people/entry/professor-stefan-pfister/) - Stefan M. Pfister, MD serves as Director of the Hopp Children´s Cancer Center (KiTZ), a joint venture between the German Cancer Research Center (DKFZ) and Heidelberg University Hospital. As one of three founding directors, he has played a pivotal role in establishing this new pediatric comprehensive cancer center, reflecting his desire to further expand the
- [Professor Richard Gilbertson](https://www.crukchildrensbraintumourcentre.org/people/entry/prof-richard-gilbertson/) - Professor Gilbertson
- [Dr David Ellison](https://www.crukchildrensbraintumourcentre.org/people/entry/dr-ellison/) - Dr Ellison's lab is working on defining molecular classification of pediatric central nervous system tumors and understanding the biology of childhood ependymoma
- [Dr Nick Gottardo](https://www.crukchildrensbraintumourcentre.org/people/entry/dr-nick-gottardo/) - Dr Gottardo is Co-Head of the Institute's Brain Tumour Research Team and a Consultant Paediatric Oncologist/Neuro-Oncologist and Head of Department of Paediatric Oncology and Haematology at Princess Margaret Hospital for Children. Dr Gottardo is also an Adjunct Associate Clinical Professor at the University of Western Australia and a Fellow of the Royal Australasian College of Physicians
- [Dr Amar Gajjar](https://www.crukchildrensbraintumourcentre.org/people/entry/dr-amar-gajjar/) - Dr. Gajjar studied medicine and completed his internship at Grant Medical College in Bombay, India. He completed an immunology research fellowship at the University of Oklahoma followed by a pediatric residency at All Children’s Hospital, University of South Florida, where he served as Chief Pediatric Resident. Dr. Gajjar then completed a pediatric hematology/oncology fellowship and
- [Dr Jenny Adamski](https://www.crukchildrensbraintumourcentre.org/people/entry/dr-jenny-adamski/) - Dr Adamski is a Neuro-Oncologist and mainly works with children and young people with brain and spinal tumours. She also cares for teenagers and young adults who are monitored for late effects of cancer treatment in childhood. She is national chair of the Children’s Cancer and Leukaemia Group (CCLG) working groups for Embryonal Tumours (including Medulloblastoma) and Choroid
- [Professor Louis Chesler](https://www.crukchildrensbraintumourcentre.org/people/entry/professor-louis-chesler/) - Professor Louis Chesler Professor Louis Chesler is working to discover and develop new drugs for children’s cancers that respond poorly to existing treatment. His research involves the three most common solid tumours of children – neuroblastoma, a nerve tumour, rhabdomyosarcoma, a muscle tumour, and medulloblastoma, a brain tumour. He leads the Paediatric Solid Tumour Biology and Therapeutics

## Patient Stories

- [Charlie Williams](https://www.crukchildrensbraintumourcentre.org/patient-stories/entry/patient-story-2/) - Charlie Williams, from Sudbury UK was just five years old when he was diagnosed with the brain tumour medulloblastoma in May 2005. He had months of treatment at the Addenbrooke’s Hospital in Cambridge, UK, including a seven hour operation, radiotherapy twice a day for five weeks and a year of chemotherapy. He missed two years
- [Emily Parsons](https://www.crukchildrensbraintumourcentre.org/patient-stories/entry/patient-story-3/) - In 2021 the Centre held a virtual event to recognise the amazing contribution that Emily Parsons and family have made to the work in the Pathania group. Emily single-handedly raised over £100,000 for research into H3K27M gliomas. Read more about Emily here. Emily is an inspiring individual, and her story is incredibly moving, motivating Centre
- [Esmé Lambert](https://www.crukchildrensbraintumourcentre.org/patient-stories/entry/esme-lambert/) - Norfolk dad reveals hidden loving tribute to his four-year old daughter for Father’s Day as she recovers from two year cancer battle Aaron Lambert, got a tattoo on the back of his head to match his daughter's brain surgery scar after a life-saving operation. The 36-year-old self-employed decorator is sharing his story to raise awareness and back

## Publications

- [Example Post 1](https://www.crukchildrensbraintumourcentre.org/publications/item/example-post-1/) - Lorem ipsum dolor sit amet, consectetur adipiscing elit. Suspendisse consequat auctor porta. Suspendisse porttitor velit nisi, non venenatis quam condimentum et.
- [Example Post 2](https://www.crukchildrensbraintumourcentre.org/publications/item/example-post-2/) - Lorem ipsum dolor sit amet, consectetur adipiscing elit. Suspendisse consequat auctor porta. Suspendisse porttitor velit nisi, non venenatis quam condimentum et.
- [Example Post 3](https://www.crukchildrensbraintumourcentre.org/publications/item/example-post-3/) - Lorem ipsum dolor sit amet, consectetur adipiscing elit. Suspendisse consequat auctor porta. Suspendisse porttitor velit nisi, non venenatis quam condimentum et.

## Resources

- [Example Post 1](https://www.crukchildrensbraintumourcentre.org/resources/item/example-post-1/) - Lorem ipsum dolor sit amet, consectetur adipiscing elit. Suspendisse consequat auctor porta. Suspendisse porttitor velit nisi, non venenatis quam condimentum et.
- [Example Post 2](https://www.crukchildrensbraintumourcentre.org/resources/item/example-post-2/) - Lorem ipsum dolor sit amet, consectetur adipiscing elit. Suspendisse consequat auctor porta. Suspendisse porttitor velit nisi, non venenatis quam condimentum et.
- [Example Post 3](https://www.crukchildrensbraintumourcentre.org/resources/item/example-post-3/) - Lorem ipsum dolor sit amet, consectetur adipiscing elit. Suspendisse consequat auctor porta. Suspendisse porttitor velit nisi, non venenatis quam condimentum et.

## Events

- [Annual Symposium 2026](https://www.crukchildrensbraintumourcentre.org/events/event/item/annual-symposium-2026/) - We are delighted to be hosting the CRUK Children's Brain Tumour Centre of Excellence annual symposium at the CRUK Cambridge Institute. Please see CBTCE Symposium May 15th 2026 for the link to the full programme. Please leave feedback for our event using this link. We are very pleased to welcome the below speakers for the
- [CBTCE International Summer School 2024 – Childhood Brain Tumour Research In The Era Of Big Data](https://www.crukchildrensbraintumourcentre.org/events/event/item/cbtce-international-summer-school-2024-childhood-brain-tumour-research-in-the-era-of-big-data/) - We are delighted to confirm the CBTCE'S International Summer School 2024 will be on the topic Childhood Brain Tumour Research in the Era of Big Data 17th - 19th July at Trinity Hall, Cambridge UK. We have an exciting programme lined up with fantastic speakers and networking opportunities for early career research scientists. Places for
- [Centre Seminar Series](https://www.crukchildrensbraintumourcentre.org/events/event/item/centre-seminar-series/) - We are excited to announce the Centre seminar series covering the latest research in Children's Brain Tumours from across the globe. More details to follow soon...
- [Ependymoma Science Meeting 'EpCam 2023'](https://www.crukchildrensbraintumourcentre.org/events/event/item/ependymoma-science-meeting-epcam-2023/) - We are excited to announce that the Centre is hosting the second Ependymoma Science meeting in Cambridge, UK this June 2023, following the success of last years meeting. The meeting is led by Professor Richard Gilbertson and Dr Michael Taylor. World leaders from Europe, North America and Australia will be in attendance to discuss the
- [The Open Academy](https://www.crukchildrensbraintumourcentre.org/events/event/item/event-demo-2/) - The Open Academy connecting early career research scientists
- [Journal Club](https://www.crukchildrensbraintumourcentre.org/events/event/item/event-demo-1/) - The Centre hosts a journal club in collaboration with AstraZeneca which gives the opportunity for early career scientists to present and have lively discussions on impactful paediatric neuro-oncology papers.

## Categories

- [News](https://www.crukchildrensbraintumourcentre.org/news/category/news/)
- [Tessa Jowell](https://www.crukchildrensbraintumourcentre.org/news/category/tessa-jowell/)
- [Stories](https://www.crukchildrensbraintumourcentre.org/news/category/stories/)
- [Cancer Research](https://www.crukchildrensbraintumourcentre.org/news/category/cancer-research/)
- [Covid-19](https://www.crukchildrensbraintumourcentre.org/news/category/covid-19/)

## Tags

- [Demo Tag 1](https://www.crukchildrensbraintumourcentre.org/news/tag/demo-tag-1/)
- [Science festival](https://www.crukchildrensbraintumourcentre.org/news/tag/science-festival/)
- [brain tumours](https://www.crukchildrensbraintumourcentre.org/news/tag/brain-tumours/)
- [public engagement](https://www.crukchildrensbraintumourcentre.org/news/tag/public-engagement/)
- [@CRUKresearch](https://www.crukchildrensbraintumourcentre.org/news/tag/crukresearch/)
- [@gilbertsonlab](https://www.crukchildrensbraintumourcentre.org/news/tag/gilbertsonlab/)
- [@ICR](https://www.crukchildrensbraintumourcentre.org/news/tag/icr/)

## Team Categories

- [Centre Group Leaders](https://www.crukchildrensbraintumourcentre.org/people/category/item/centre-group-leaders/)
- [Centre Directors](https://www.crukchildrensbraintumourcentre.org/people/category/item/centre-directors/)
- [International Children's Brain Tumour Board](https://www.crukchildrensbraintumourcentre.org/people/category/item/international-childrens-brain-tumour-board/) - The International Children’s Brain Tumour Board meet to …
- [The New Roads Team; Innovative Approaches to Curing Brain Tumours](https://www.crukchildrensbraintumourcentre.org/people/category/item/the-new-roads-team-innovative-approaches-to-curing-brain-tumours/)
- [Scientific Manager](https://www.crukchildrensbraintumourcentre.org/people/category/item/scientific-manager/)

## Event Categories

- [Training & Development](https://www.crukchildrensbraintumourcentre.org/events/category/item/training-development/)
- [Conferences & Events](https://www.crukchildrensbraintumourcentre.org/events/category/item/conferences-events/)